Caution patients that some people have a variation in a liver enzyme and change codeine into morphine more rapidly and completely than other people.
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Patients with DRA may also develop hollow cavities, or cysts, in some of their bones; these may lead to unexpected bone fractures.
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Pregnancy Category C—Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels.
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But, in some cases, health care providers cannot determine a cause for infertility in the man or woman.
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Affected individuals have only moderate enlargement of the spleen and liver, but brain damage may be extensive and cause an inability to look up and down, difficulty in walking and swallowing, and progressive loss of vision and hearing.
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Pharmacology/toxicology studies showed an effect both in prolonging QTc interval in dogs in vivo and in vitro action potential duration (APD) in rabbit Purkinje fibers.
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As discussed earlier (see WARNINGS 1a and 1d), changes in serum triglycerides and lipoprotein levels have been reported in oral contraceptive users.
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The NIDDK is part of the National Institutes of Health under the U.S. Department of Health and Human Services.
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Squamous cell carcinoma occurs on areas of the skin that have been in the sun, such as the ears, lower lip, and the back of the hands.
